tert-Butanol → HCID 18426153, compound
Reaction equation
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][N:7]2[CH2:15][CH2:14][CH2:13][CH:9](C(O)=O)[CH2:8]2)=[CH:4][CH:3]=1.CC[N:20]([CH2:23]C)CC.C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:32])C=CC=CC=1.[CH3:42][C:43]([OH:46])([CH3:45])[CH3:44]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[CH2:15][CH2:14][CH2:13][CH:9]([NH:20][C:23]([O:46][C:43]([CH3:45])([CH3:44])[CH3:42])=[O:32])[CH2:8]2)=[CH:16][CH:17]=1Participants
Procedure
A solution of 1-(4-chlorobenzyl)nipecotic acid (7.06 g, 27.8 mmol) in tBuOH (500 mL) was treated with Et3N (3.38 g) and activated 3 A molecular sieves (30 g). Diphenylphosphoryl azide (8.58 g) was added, and the reaction mixture was warmed at reflux for 18 h. The mixture was cooled and the solvent was ref for 18 h. The mixture was cooled and the solvent was remove under vacuum. Tie residue was dissolved in EtOAc (500 mL), and the organic phase was washed with saturated aqueous NaHCO3 (2×100 mL) and brine (50 mL), dried (Na2SO4), and concentrated in vacuo. Chromatography (SiO2, 25% EtOAc-hexane) afforded 1-(4-chlorobenzyl)-3-{(tert-butoxycarbonyl)amino}piperidine (2.95 g, 32.6%) as a white crystalline solid: 1H NMR (CDCl3, 300 MHz) δ1.4-1.75 (br, 4 H), 2.2-2.7 (br, 4 H), 3.5 (br, 2 H), 3.8 (br, 1 H), 7.3 (br, 4 H); The purity was determined by RPLC/MS (>99%); ESI/MS m/e 269.2 (M++H−56, C17H26ClN2O2).
Workup
- temperaturethe reaction mixture was warmed
- temperatureat reflux for 18 h
- temperatureThe mixture was cooled
- temperatureThe mixture was cooled
- customthe solvent was remove under vacuum
- dissolutionwas dissolved in EtOAc (500 mL)
- washthe organic phase was washed with saturated aqueous NaHCO3 (2×100 mL) and brine (50 mL)
- dry with materialdried (Na2SO4)
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-27269e9ab98b400598d5de6be8f0d68c
- Source dataset
- uspto-grants-2002_09
- Patent number
- US06451842B1
Reaction notes
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