Piperidine → HCID 15516358, compound

HRID 1281095Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH2:14][CH2:13][C:12](=[O:15])[NH:11][C:10]2=[O:16])[CH:5]=[CH:6][C:7]=1[Cl:8].[NH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[C:10]([C:9]([C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)([CH2:14][CH2:13][C:12]([N:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1)=[O:15])[CH2:17][CH2:18][C:19]([OH:21])=[O:20])(=[O:16])[NH2:11]

Participants

Reactant 2

HCID 8082Piperidine

HCID 11121055HCID 11121055, compound

Product 1

HCID 15516358HCID 15516358, compound

Procedure

0.3 g of 3-[3-(3,4-dichlorophenyl)-2,6-dioxopiperidin-3-yl]propionic acid of S configuration is treated with piperidine as described in Preparation 3 to give 0.3 g of the expected compound.

Workup

customas described in Preparation 3

Sources & evidence

ORD record: ord-2cbc351697624ec4a3122181bbbf1767
Source dataset: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06452012B1

Reaction notes

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