Hydrochloric Acid → HCID 11020735, compound

HRID 1281100Notes

Reaction equation

HRID 1281100 reaction equation
[NH2:1][C:2]1[C:11]([Cl:12])=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[C:4]([O:13][CH3:14])[C:3]=1[O:15][CH3:16].[OH-].[K+].Cl>O>[NH2:1][C:2]1[C:11]([Cl:12])=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[C:4]([O:13][CH3:14])[C:3]=1[O:15][CH3:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 22708816HCID 22708816, compound

Product 1

HCID 11020735HCID 11020735, compoundYield 84.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of intermediate (2-d) (0.27 mol) and potassium hydroxide (2.7 mol) in water (1000 ml) was stirred and refluxed for 2 hours. The reaction mixture was cooled and acidified with hydrochloric acid (36%), and the resulting precipitate was filtered off, washed with water and dried, yielding 53 g (84.8%) of 4-amino-5-chloro-2,3-di-methoxybenzoic acid (interm. 2-e).

Workup

  1. temperaturerefluxed for 2 hours
  2. temperatureThe reaction mixture was cooled
  3. filtrationthe resulting precipitate was filtered off
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-1bf2ee5646d64426b2e4680066f44a0a
Source dataset
uspto-grants-2002_09
Patent number
US06452013B1

Reaction notes

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