2-Chloro-5-(chloromethyl)thiophene → 1-(5-Chlorothiophen-2-ylmethyl)-5,6-dichloro2-(4-formylphenyl)benzimidazole

HRID 1281130Notes

Reaction equation

HRID 1281130 reaction equation
[Cl:1][C:2]1[C:18]([Cl:19])=[CH:17][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:12]([CH:15]=[O:16])=[CH:11][CH:10]=3)[NH:8][C:4]=2[CH:3]=1.[Cl:20][C:21]1[S:22][C:23]([CH2:26]Cl)=[CH:24][CH:25]=1>>[Cl:20][C:21]1[S:22][C:23]([CH2:26][N:8]2[C:4]3[CH:3]=[C:2]([Cl:1])[C:18]([Cl:19])=[CH:17][C:5]=3[N:6]=[C:7]2[C:9]2[CH:10]=[CH:11][C:12]([CH:15]=[O:16])=[CH:13][CH:14]=2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 5830792-Chloro-5-(chloromethyl)thiopheneHCID 184267935,6-Dichloro-2-(4-formylphenyl)benzimidazole

Product 1

HCID 184268581-(5-Chlorothiophen-2-ylmethyl)-5,6-dichloro2-(4-formylphenyl)benzimidazole

Procedure

1-(5-Chlorothiophen-2-ylmethyl)-5,6-dichloro2-(4-formylphenyl)benzimidazole was prepared from 5,6-dichloro-2-(4-formylphenyl)benzimidazole obtained in Example 13 and 2-chloro-5-chloromethylthiophene by following General Procedure 3.

Sources & evidence

ORD record
ord-75e41803c6164cb7bac3f252ca086eda
Source dataset
uspto-grants-2002_09
Patent number
US06452014B1

Reaction notes

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