2-(Chloromethyl)quinoline → 5,6-Dichloro-2-(4-formylphenyl)-1-(quinolin-2-ylmethyl)benzimidazole

HRID 1281131Notes

Reaction equation

HRID 1281131 reaction equation
[Cl:1][C:2]1[C:18]([Cl:19])=[CH:17][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:12]([CH:15]=[O:16])=[CH:11][CH:10]=3)[NH:8][C:4]=2[CH:3]=1.Cl[CH2:21][C:22]1[CH:31]=[CH:30][C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[N:23]=1>>[Cl:19][C:18]1[C:2]([Cl:1])=[CH:3][C:4]2[N:8]([CH2:21][C:22]3[CH:31]=[CH:30][C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[N:23]=3)[C:7]([C:9]3[CH:10]=[CH:11][C:12]([CH:15]=[O:16])=[CH:13][CH:14]=3)=[N:6][C:5]=2[CH:17]=1

Participants

3

Reactant 2

HCID 203942-(Chloromethyl)quinolineHCID 184267935,6-Dichloro-2-(4-formylphenyl)benzimidazole

Product 1

HCID 184268295,6-Dichloro-2-(4-formylphenyl)-1-(quinolin-2-ylmethyl)benzimidazole

Procedure

5,6-dichloro-2-(4-formylphenyl)-1-(quinolin-2-ylmethyl)benzimidazole was prepared from 5,6-dichloro-2-(4-formylphenyl)benzimidazole obtained in Example 13 and 2-chloromethylquinoline by following General Procedure 3.

Sources & evidence

ORD record
ord-f98b774695cc4caaae8088650275425c
Source dataset
uspto-grants-2002_09
Patent number
US06452014B1

Reaction notes

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