反应详情

To a solution of 4-bromo-2-fluorobenzaldehyde (3.97 g, 18.8 mmol) in methanol (200 mL) was added p-toluenesulfonic acid monohydrate (357 mg, 1.88 mmol), and the mixture was heated to reflux for 4 h. Aqueous sodium carbonate (1 mol/L; 2 mL) was added, and the mixture was concentrated to a volume of ca. 50 mL and extracted with ether. The organic layer was washed with brine and dried on anhydrous sodium sulfate. The solvent was removed under reduced pressure to afford 4-bromo-1-dimethoxymethyl-2-fluorobenzene (4.56 g, 97%).

1. temperaturethe mixture was heated
2. temperatureto reflux for 4 h
3. concentrationthe mixture was concentrated to a volume of ca. 50 mL
4. extractionextracted with ether
5. washThe organic layer was washed with brine
6. dry with materialdried on anhydrous sodium sulfate
7. customThe solvent was removed under reduced pressure