Hydroxyamine hydrochloride → HCID 86587304, compound

HRID 1281170Notes

Reaction equation

HRID 1281170 reaction equation
[C:1]([C:4]1[C:9]2[CH:10]([C:12]#[N:13])[CH2:11][C:8]=2[CH:7]=[CH:6][CH:5]=1)(=O)[CH3:2].Cl.[NH2:15][OH:16]>N1C=CC=CC=1.ClCCl.O>[OH:16][N:15]=[CH:2][CH2:1][C:4]1[C:9]2[CH:10]([C:12]#[N:13])[CH2:11][C:8]=2[CH:7]=[CH:6][CH:5]=1

Participants

6

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 22714702HCID 22714702, compound

Product 1

HCID 86587304HCID 86587304, compound

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 1049PyridineSolventHCID 6344DichloromethaneSolvent

Procedure

10.07 g of the product of Step 1 and 6.13 g of hydroxylamine hydrochloride in 200 ml of pyridine are stirred at ambient temperature for 19 hours. After removal of the pyridine by evaporation, the yellow oil obtained is taken up in dichloromethane and water. The organic phase is removed, dried and concentrated, allowing the expected product to be isolated.

Workup

  1. customAfter removal of the pyridine
  2. customby evaporation
  3. customthe yellow oil obtained
  4. customThe organic phase is removed
  5. customdried
  6. concentrationconcentrated
  7. customto be isolated

Sources & evidence

ORD record
ord-9ab1ed17ddf445299828c13b6bc44513
Source dataset
uspto-grants-2002_09
Patent number
US06452015B2

Reaction notes

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