HCID 23382082, compound → HCID 23382080, compound

HRID 1281188Notes

Reaction equation

HRID 1281188 reaction equation
[N:1]1[N:2]=[CH:3][N:4]([C:6]2[CH:11]=[CH:10][C:9]([CH2:12][N:13]([NH:37]C(OC(C)(C)C)=O)[CH2:14][C@H:15]([OH:36])[C@@H:16]([NH:24][C:25](=[O:35])[C@H:26]([CH:32]([CH3:34])[CH3:33])[NH:27][C:28]([O:30][CH3:31])=[O:29])[CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:8][CH:7]=2)[CH:5]=1>C(O)=O>[N:1]1[N:2]=[CH:3][N:4]([C:6]2[CH:11]=[CH:10][C:9]([CH2:12][N:13]([NH2:37])[CH2:14][C@H:15]([OH:36])[C@@H:16]([NH:24][C:25](=[O:35])[C@H:26]([CH:32]([CH3:34])[CH3:33])[NH:27][C:28]([O:30][CH3:31])=[O:29])[CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:8][CH:7]=2)[CH:5]=1

Participants

3

Reactant 1

HCID 23382082HCID 23382082, compound

Product 1

HCID 23382080HCID 23382080, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

0.543 g (0.89 mmol) of 1-[p-(1,2,4-triazol-4-yl)phenyl]-4(S)-hydroxy-2-(tert-butyloxycarbonyl)amino-5(S)-[N-(N-methoxycarbonyl-(L)-valyl)amino]-6-phenyl-2-azahexane (Example 14f) is stirred in 20 ml of formic acid at RT for 4 h under nitrogen. The formic acid is removed, the residue is taken up in methylene chloride, and the organic phase is washed with a sat. solution of sodium bicarbonate. The title compound is isolated as a yellow foam, which is subjected to further processing without being purified.

Workup

  1. customThe formic acid is removed
  2. washthe organic phase is washed with a sat. solution of sodium bicarbonate

Sources & evidence

ORD record
ord-a73a8f59ff0143e5aff7117b7cabb570
Source dataset
uspto-grants-2002_09
Patent number
US06451973B1

Reaction notes

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