反应详情

温度

30 °C

A solution of N-tert-butoxycarbonyl-3(S)-amino-2(R)-hydroxy-4-phenylbutyric acid methyl ester 85.1 kg dissolved in ethanol 220 kg was kept at 10-20° C. and mixed with sodium borohydride 13.5 kg and stirred at 15-45° C. for 3 hrs. The reaction solution was cooled, adjusted with 3N-HCl to pH 2.5-3.5, concentrated under a reduced pressure, and washed with ethyl acetate and water to separate an organic phase, which was washed with aqueous 10% sodium chloride solution and concentrated under an reduced pressure to obtain the crude N-tert-butoxycarbonyl-3(S)-amino-2(R)-hydroxy-4-phenyl-1-butanol.

1. customwas kept at 10-20° C.
2. temperatureThe reaction solution was cooled
3. concentrationconcentrated under a reduced pressure
4. washwashed with ethyl acetate and water
5. customto separate an organic phase, which
6. washwas washed with aqueous 10% sodium chloride solution
7. concentrationconcentrated under an reduced pressure