HCID 131722605, compound → HCID 70147894, compound

HRID 1281212Notes

Reaction equation

HRID 1281212 reaction equation
[C:1]([O:4][C@H:5]1[CH:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH:21]([CH3:23])[CH3:22])=[O:19])[C@H:8]([CH2:24][O:25][Si](C(C)(C)C)(C)C)[C@H:7]([O:33][CH:34]2[CH2:39][CH2:38][CH2:37][CH2:36][O:35]2)[CH2:6]1)(=[O:3])[CH3:2]>C1COCC1.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>[C:1]([O:4][C@H:5]1[CH:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH:21]([CH3:22])[CH3:23])=[O:19])[C@H:8]([CH2:24][OH:25])[C@H:7]([O:33][CH:34]2[CH2:39][CH2:38][CH2:37][CH2:36][O:35]2)[CH2:6]1)(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 131722605HCID 131722605, compound

Product 1

HCID 70147894HCID 70147894, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 2724141Tetrabutylammonium FluorideSolvent

Procedure

To the solution of the compound (13-3)(4.05 g) in THF(8 ml), tetrabutylammonium fluoride (1M, THF solution, 8.51 ml) was added at room temperature and the mixture was left overnight. The crude product obtained by the conventional treatment was purified by silica gel chromatography (n-hexane/ethyl acetate=6/4) to give the titled compound (13-4).

Workup

  1. customThe crude product obtained by the conventional treatment
  2. customwas purified by silica gel chromatography (n-hexane/ethyl acetate=6/4)

Sources & evidence

ORD record
ord-09fc7aa52ce546d399f02b86d99ff411
Source dataset
uspto-grants-2002_09
Patent number
US06452039B1

Reaction notes

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