Isopropyl iodide → HCID 59910744, compound

HRID 1281214Notes

Reaction equation

HRID 1281214 reaction equation
[OH:1][C@@H:2]1[CH2:6][C@H:5]([OH:7])[C@H:4]([CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])[C@H:3]1[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28].[CH:29](I)([CH3:31])[CH3:30].C1CCN2C(=NCCC2)CC1>C(#N)C>[OH:1][C@@H:2]1[CH2:6][C@H:5]([OH:7])[C@H:4]([CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18][CH:29]([CH3:31])[CH3:30])=[O:17])[C@H:3]1[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

Participants

5

Reactant 3

HCID 6362Isopropyl iodideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 59910740HCID 59910740, compound

Product 1

HCID 59910744HCID 59910744, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The compound (27-5) was reacted with isopropyl iodide and DBU in dry acetonitrile and the resultant was purified on silica gel column to give the titled compound (27-6).

Workup

  1. customthe resultant was purified on silica gel column

Sources & evidence

ORD record
ord-18a892982d7e4048b57c1da3b49fecea
Source dataset
uspto-grants-2002_09
Patent number
US06452039B1

Reaction notes

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