Water → Chlorthal

HRID 1281221Notes

Reaction equation

[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([C:9](N)=[O:10])[C:5]([Cl:12])=[C:4]([Cl:13])[C:3]=1[C:14](N)=[O:15].[OH2:17].S(=O)(=O)(O)[OH:19]>>[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([C:9]([OH:10])=[O:17])[C:5]([Cl:12])=[C:4]([Cl:13])[C:3]=1[C:14]([OH:15])=[O:19]

Participants

Reactant 3

HCID 962Water

HCID 1118Sulfuric Acid

HCID 113240872,3,5,6-tetrachloro-1,4-benzenedicarboxamide

Product 1

HCID 16493Chlorthal

Procedure

In the hydrolysis of 2,3,5,6-tetrachloro-1, 4-benzenedicarboxamide, as is apparent from Examples 4 and 5, the maximum reduction of the amount of water in sulfuric acid resulted in efficiently forming desired 2,3,5,6-tetrachloro-1,4-benzenedicarboxylic acid by heating 2,3,5,6-tetrachloro-1,4-benzenedicarboxamide at 180 or 130° C. for 7 or 27 hr.

Sources & evidence

ORD record: ord-cd675f3a0acd4764bca6237d1da57827
Source dataset: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06452046B2

Reaction notes

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