HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86615969, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 5-(2-fluoro-3-pyridinyl)-1-(4-{(1S)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}butyl)-2,4(1H,3H)-pyrimidinedione | HCID 68692354 | — |
| Product | HCID 86615969 | HCID 86615969 | 89% |
Reaction Steps
5-(2-fluoro-3-pyridinyl)-1-(4-{(1S)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}butyl)-2,4(1H,3H)-pyrimidinedione was treated with 4N HCl in dioxane (2 eq). After evaporation of the solvent and trituration with diethyl ether, 41 mg of the title compound were obtained as a white powder. (89% yield)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727988B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-d8a25331bdad41cb84ed27154e32bea6 |
| Source note | uspto-grants-2010_06 |