HCID 70132990, compound → HCID 10167042, compound

HRID 1281555Notes

Reaction equation

HRID 1281555 reaction equation
[OH:1][C@H:2]([CH2:35][O:36][C:37]1[CH:42]=[CH:41][C:40]([O:43][Si](C(C)C)(C2C=CC=CC=2)C2C=CC=CC=2)=[CH:39][CH:38]=1)[CH2:3][NH:4][CH2:5][CH2:6][C:7]1[CH:34]=[CH:33][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([NH:20][C:21]3[CH:32]=[CH:31][C:24]([O:25][CH2:26][C:27]([O:29]C)=[O:28])=[CH:23][CH:22]=3)=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1>C(Cl)(Cl)Cl.CO>[OH:1][C@H:2]([CH2:35][O:36][C:37]1[CH:38]=[CH:39][C:40]([OH:43])=[CH:41][CH:42]=1)[CH2:3][NH:4][CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([NH:11][CH:12]2[CH2:13][CH2:14][N:15]([C:18]([NH:20][C:21]3[CH:22]=[CH:23][C:24]([O:25][CH2:26][C:27]([OH:29])=[O:28])=[CH:31][CH:32]=3)=[O:19])[CH2:16][CH2:17]2)=[CH:33][CH:34]=1

Participants

3

Reactant 1

HCID 70132990HCID 70132990, compound

Product 1

HCID 10167042HCID 10167042, compoundYield 56.3%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Methyl 2-{4-[({4-[4-(2-{[(2S)-2-hydroxy-3-(4-{[isopropyl(diphenyl)silyl]oxy}phenoxy)propyl]amino}ethyl)anilino]piperidinyl}carbonyl)amino]phenoxy}acetate (0.16 g, 0.192 mmol) was reacted according to Procedure H (eluant: 10:1 going to 5:1 chloroform-methanol containing 2% triethylamine) to give the title compound (0.64 g, 0.108 mmol)

Sources & evidence

ORD record
ord-dbbf4715047d4c319a3415c6204e9b4d
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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