Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10168591, compound

HRID 1281566Notes

Reaction equation

HRID 1281566 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:39]=[CH:38][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([NH:20][CH2:21][C:22]3[CH:27]=[CH:26][C:25]([NH:28][C:29]([NH:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])=[O:30])=[CH:24][CH:23]=3)=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1.C([Si]([O:57][C:58]1[CH:63]=[CH:62][C:61]([O:64][CH2:65][CH:66]2[CH2:68][O:67]2)=[CH:60][CH:59]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[CH2:32]([NH:31][C:29](=[O:30])[NH:28][C:25]1[CH:26]=[CH:27][C:22]([CH2:21][NH:20][C:18]([N:15]2[CH2:16][CH2:17][CH:12]([NH:11][C:10]3[CH:9]=[CH:8][C:7]([CH2:6][CH2:5][NH:4][CH2:68][C@H:66]([OH:67])[CH2:65][O:64][C:61]4[CH:62]=[CH:63][C:58]([OH:57])=[CH:59][CH:60]=4)=[CH:39][CH:38]=3)[CH2:13][CH2:14]2)=[O:19])=[CH:23][CH:24]=1)[CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 70133039HCID 70133039, compound

Product 1

HCID 10168591HCID 10168591, compoundYield 29.4%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-[4-(2-Aminoethyl)anilino]-N-(4-{[(hexylamino)carbonyl]amino}benzyl)-1-piperidinecarboxamide formate (0.29 g, 0.54 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.220 g, 0.54 mmol) according to Procedure G (eluant: 20:1 going to 10:1 chloroform-methanol) to give the title compound (0.143 g, 0.159 mmol).

Sources & evidence

ORD record
ord-cee94fd6a0634250bd900a6700fb782f
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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