HCID 70029000, compound → HCID 10168591, compound

HRID 1281567Notes

Reaction equation

HRID 1281567 reaction equation
[Si]([O:18][C:19]1[CH:65]=[CH:64][C:22]([O:23][CH2:24][C@@H:25]([OH:63])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:62]=[CH:61][C:33]([NH:34][CH:35]3[CH2:40][CH2:39][N:38]([C:41]([NH:43][CH2:44][C:45]4[CH:50]=[CH:49][C:48]([NH:51][C:52]([NH:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH3:60])=[O:53])=[CH:47][CH:46]=4)=[O:42])[CH2:37][CH2:36]3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[CH2:55]([NH:54][C:52](=[O:53])[NH:51][C:48]1[CH:47]=[CH:46][C:45]([CH2:44][NH:43][C:41]([N:38]2[CH2:39][CH2:40][CH:35]([NH:34][C:33]3[CH:61]=[CH:62][C:30]([CH2:29][CH2:28][NH:27][CH2:26][C@H:25]([OH:63])[CH2:24][O:23][C:22]4[CH:21]=[CH:20][C:19]([OH:18])=[CH:65][CH:64]=4)=[CH:31][CH:32]=3)[CH2:36][CH2:37]2)=[O:42])=[CH:50][CH:49]=1)[CH2:56][CH2:57][CH2:58][CH2:59][CH3:60]

Participants

3

Reactant 1

HCID 70029000HCID 70029000, compound

Product 1

HCID 10168591HCID 10168591, compoundYield 75.5%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)aniiino]-N-(4-{[(hexylamino)carbonyl]amino}benzyl)-1-piperidinecarboxamide (0.143 g, 0.159 mmol) was reacted according to Procedure H (eluant: 10:1 going to 5:1 chloroform-methanol containing 2% triethylamine) to give the title compound (0.077 g, 0.12 mmol).

Sources & evidence

ORD record
ord-227ac003843c46cf8ff354bb81c7933f
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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