Sodium ethoxide → Ethyl 5-isocyanato-2-methylbenzene-1-sulfonate

HRID 128160Notes

Reaction equation

C[O-].[Na+].[CH3:4][CH2:5][O-:6].[Na+].[C:8]1([CH3:18])[C:9]([S:14](Cl)(=[O:16])=[O:15])=[CH:10][CH:11]=[CH:12][CH:13]=1.[NH2:19][C:20](OCC)=[O:21]>>[CH2:5]([O:6][S:14]([C:9]1[C:8]([CH3:18])=[CH:13][CH:12]=[C:11]([N:19]=[C:20]=[O:21])[CH:10]=1)(=[O:16])=[O:15])[CH3:4]

Participants

Reactant 3

HCID 2723922Sodium ethoxide

HCID 10942334Sodium Methoxide

HCID 88756610HCID 88756610, compound

Product 1

HCID 54358193Ethyl 5-isocyanato-2-methylbenzene-1-sulfonate

Procedure

If, instead of sodium methylate, sodium ethylate in solution in alcohol is used for esterifying the urethane toluene-2-sulphonic acid chloride according to Example 1, the 4-isocyanatotoluene-2-sulphonic acid ethyl ester is similarly obtained.

Sources & evidence

ORD record: ord-2d61740315d344d098d26912de7c4fb7
Source dataset: uspto-grants-1981_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04259255

Reaction notes

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