反应详情

In the glass liner of a stainless steel bomb cooled to -78° is condensed 10 ml. of methylamine. To this is added 0.5 ml. of 2 M n-butyllithium (in hexane), followed by 5.0 g. of 2-benzoyl-3-methoxycrotononitrile. The bomb is sealed and heated on a steam bath overnight. The bomb is then cooled, opened and the contents evaporated. The residue is dissolved in chloroform, passed through a Magnesol® pad and the filtrate is evaporated. The residue is recrystallized from chloroform-hexane yielding the title compound.

1. customcondensed 10 ml
2. additionTo this is added 0.5 ml
3. customThe bomb is sealed
4. temperatureheated on a steam bath overnight
5. temperatureThe bomb is then cooled
6. customthe contents evaporated
7. dissolutionThe residue is dissolved in chloroform
8. customthe filtrate is evaporated
9. customThe residue is recrystallized from chloroform-hexane yielding the title compound