1,3,5-Trifluoro-2-nitrobenzene → HCID 18422318, compound

HRID 1281760Notes

Reaction equation

HRID 1281760 reaction equation
[NH2:1][C:2]1[S:6][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[C:3]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12].[F:16][C:17]1[CH:22]=[C:21]([F:23])[CH:20]=[C:19](F)[C:18]=1[N+:25]([O-:27])=[O:26]>CS(C)=O>[F:16][C:17]1[C:18]([N+:25]([O-:27])=[O:26])=[C:19]([CH:20]=[C:21]([F:23])[CH:22]=1)[NH:1][C:2]1[S:6][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[C:3]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

4

Reactant 2

HCID 675671,3,5-Trifluoro-2-nitrobenzeneHCID 699464Ethyl 2-amino-1-benzothiophene-3-carboxylate

Product 1

HCID 18422318HCID 18422318, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In the same manner as in Starting Material Synthesis Example 4 and using ethyl 2-aminobenzo[b]thiophene-3-carboxylate, 2,4,6-trifluoronitrobenzene and dimethyl sulfoxide, ethyl 2-(3,5-difluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylate is obtained.

Workup

  1. customMaterial Synthesis Example 4

Sources & evidence

ORD record
ord-a188b08e7cbb41b0a17757ac218c606f
Source dataset
uspto-grants-2002_09
Patent number
US06455521B1

Reaction notes

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