HCID 18422318, compound → HCID 18422356, compound

HRID 1281773Notes

Reaction equation

HRID 1281773 reaction equation
[F:1][C:2]1[C:3]([N+:24]([O-])=O)=[C:4]([CH:20]=[C:21]([F:23])[CH:22]=1)[NH:5][C:6]1[S:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[C:7]=1[C:15]([O:17][CH2:18][CH3:19])=[O:16].[H][H]>[C].[Pd].C(OCC)(=O)C>[NH2:24][C:3]1[C:2]([F:1])=[CH:22][C:21]([F:23])=[CH:20][C:4]=1[NH:5][C:6]1[S:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[C:7]=1[C:15]([O:17][CH2:18][CH3:19])=[O:16]

Participants

5

Reactant 2

HCID 18422318HCID 18422318, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18422356HCID 18422356, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

In the same manner as in Starting Material Synthesis Example 19 and using ethyl 2-(3,5-difluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylate, ethyl acetate, 10% palladium-carbon and hydrogen (60 atm kg/cm2), ethyl 2-(2-amino-3,5-difluoroanilino)benzo[b]thiophene-3-carboxylate is obtained.

Workup

  1. customMaterial Synthesis Example 19

Sources & evidence

ORD record
ord-6961f71bf3f441afb727520be41d19bd
Source dataset
uspto-grants-2002_09
Patent number
US06455521B1

Reaction notes

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