反应详情

148 g (0.6 mol) of ethyl 3-amino-4-(2-methoxyphenyl)-2-methylbutanoate 13 and 119 g (1.2 mol) of ethyl acrylate are dissolved in 250 mL of abs. ethanol and refluxed for 6 h. Then the mixture is concentrated by evaporation in vacuo. The residue is again taken up in 300 mL of toluene and once more concentrated by evaporation in vacuo. 210 g (100%) of the desired product are isolated as an oil.

1. concentrationThen the mixture is concentrated by evaporation in vacuo
2. concentrationonce more concentrated by evaporation in vacuo