HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 1-(2-Phenylpropyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 1-Bromo-2-phenylpropane | HCID 97813 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(2-Phenylpropyl)piperazine | HCID 20508973 | — |
Reaction Steps
A solution of piperazine (344 g), β-bromoisopropylbenzene (199 g) in water (1 liter) and ethanol (0.35 liter) is refluxed for 24 hours. After cooling, the resulting amine is extracted with 3×0.5 liter methylene chloride. After washing with water and evaporation of the solvent in vacuo, the resulting 2-phenylpropyl piperazine is distilled; b.p.=163°-165° C./15 mm Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04259334 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-410e50dca39446c98a64a81e9efa670f |
| Source note | uspto-grants-1981_03 |