反应详情

A solution of piperazine (344 g), β-bromoisopropylbenzene (199 g) in water (1 liter) and ethanol (0.35 liter) is refluxed for 24 hours. After cooling, the resulting amine is extracted with 3×0.5 liter methylene chloride. After washing with water and evaporation of the solvent in vacuo, the resulting 2-phenylpropyl piperazine is distilled; b.p.=163°-165° C./15 mm Hg.

1. temperatureAfter cooling
2. extractionthe resulting amine is extracted with 3×0.5 liter methylene chloride
3. washAfter washing with water and evaporation of the solvent in vacuo
4. distillationthe resulting 2-phenylpropyl piperazine is distilled