4-Amino-3,5-dimethylisoxazole → HCID 9862320, compound

HRID 1282040Notes

Reaction equation

HRID 1282040 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:15]([OH:17])=O)=[C:7]2[C:11]=1[O:10][C:9]([CH2:12][O:13][CH3:14])=[CH:8]2.[CH3:18][C:19]1[C:23]([NH2:24])=[C:22]([CH3:25])[O:21][N:20]=1>>[CH3:18][C:19]1[C:23]([NH:24][C:15]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[C:11]3[O:10][C:9]([CH2:12][O:13][CH3:14])=[CH:8][C:7]=23)=[O:17])=[C:22]([CH3:25])[O:21][N:20]=1

Participants

3

Reactant 2

HCID 1820404-Amino-3,5-dimethylisoxazoleHCID 18423641HCID 18423641, compound

Product 1

HCID 9862320HCID 9862320, compoundYield 69.4%

Procedure

Starting from 7-methoxy-2-methoxymethylbenzofuran-4-carboxylic acid (0.19 g) and 3,5-dimethylisoxazol-4-ylamine (88 mg). Purification by column chromatography on silica eluting with ethyl acetate afforded the title compound as a cream solid (0.18 g).

Workup

  1. customPurification by column chromatography on silica eluting with ethyl acetate

Sources & evidence

ORD record
ord-e4399eb88f1e4dd5b69f17f5a1b2b566
Source dataset
uspto-grants-2002_09
Patent number
US06455561B1

Reaction notes

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