1-(2-Methoxyphenyl)piperazine → HCID 18423158, compound

HRID 1282065Notes

Reaction equation

HRID 1282065 reaction equation
[Cl:1][CH:2]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][NH:11][C:12](=[O:14])[CH3:13])=[CH:6][CH:5]=1)[CH3:3].[Cl:15]CC1C=CC(CNC(=O)C)=CC=1.[CH3:28][O:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[N:36]1[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1.Cl.O1CCOCC1>C(O)C>[ClH:1].[ClH:15].[CH3:28][O:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[N:36]1[CH2:41][CH2:40][N:39]([CH:2]([C:4]2[CH:9]=[CH:8][C:7]([CH2:10][NH:11][C:12](=[O:14])[CH3:13])=[CH:6][CH:5]=2)[CH3:3])[CH2:38][CH2:37]1

Participants

6

Reactant 4

HCID 13461-(2-Methoxyphenyl)piperazineHCID 15550682N-((4-(chloromethyl)phenyl)methyl)acetamideHCID 18423036N-(4-(1-chloroethyl)phenylmethyl)acetamideHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 18423158HCID 18423158, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In Example 1(5), N-((4-(1-chloroethyl)phenyl)methyl)acetamide was used for reaction instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(2-methoxyphenyl)piperazine instead of 1-phenylpiperazine, which was followed by treatment with 4M hydrochloric acid-dioxane in ethanol to give the title compound as white crystals.

Sources & evidence

ORD record
ord-0a331dc079e94ae49fdb1a05ea018a17
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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