Hydrochloric Acid → HCID 18423035, compound

Participants

Reaction Steps

1-Acetyl-4-(4-fluoro-2-hydroxyphenyl)piperazine (0.64 g) was dissolved in a 1.2N aqueous hydrochloric acid solution (16 ml) and refluxed under heating for 7 days. The reaction mixture was concentrated under reduced pressure to give a pale-brown solid. This solid was recrystallized from methanol-ethyl acetate to give the title compound (0.65 g) as pale-brown crystals.

Provenance & Evidence