Hydrochloric Acid → HCID 18423035, compound

HRID 1282086Notes

Reaction equation

HRID 1282086 reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[OH:17])[CH2:6][CH2:5]1)(=O)C.[ClH:18]>>[ClH:18].[ClH:18].[F:16][C:13]1[CH:14]=[CH:15][C:10]([N:7]2[CH2:6][CH2:5][NH:4][CH2:9][CH2:8]2)=[C:11]([OH:17])[CH:12]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 18423178HCID 18423178, compound

Product 1

HCID 18423035HCID 18423035, compound

Procedure

1-Acetyl-4-(4-fluoro-2-hydroxyphenyl)piperazine (0.64 g) was dissolved in a 1.2N aqueous hydrochloric acid solution (16 ml) and refluxed under heating for 7 days. The reaction mixture was concentrated under reduced pressure to give a pale-brown solid. This solid was recrystallized from methanol-ethyl acetate to give the title compound (0.65 g) as pale-brown crystals.

Workup

  1. temperaturerefluxed
  2. temperatureunder heating for 7 days
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customto give a pale-brown solid
  5. customThis solid was recrystallized from methanol-ethyl acetate

Sources & evidence

ORD record
ord-d479a76381d34c0ca6f1e308faf86f4c
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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