1-(4-Fluorophenyl)piperazine → HCID 11588436, compound

HRID 1282089Notes

Reaction equation

HRID 1282089 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl[CH2:15][C:16]1[CH:21]=[CH:20][C:19]([CH:22]([NH:24][C:25](=[O:27])[CH3:26])[CH3:23])=[CH:18][CH:17]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:15][C:16]3[CH:17]=[CH:18][C:19]([CH:22]([NH:24][C:25](=[O:27])[CH3:26])[CH3:23])=[CH:20][CH:21]=3)[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 752601-(4-Fluorophenyl)piperazineHCID 18423033N-(1-(4-chloromethylphenyl)ethyl)acetamide

Product 1

HCID 11588436HCID 11588436, compound

Procedure

By similar reaction and treatment to that in Example 1(5) using 1-(4-fluorophenyl)piperazine instead of phenylpiperazine and N-(1-(4-chloromethylphenyl)ethyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide, the title compound was obtained as white crystals, m.p.=101-103° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-66682aed1f0f4c728006ed74f99bd26c
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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