1-(2,4-Difluorophenyl)piperazine dihydrochloride → N-(1-methyl-1-(4-((4-(2,4-difluorophenyl)piperazin-1-yl)methyl)phenyl)ethyl)acetamide hydrochloride

HRID 1282093Notes

Reaction equation

HRID 1282093 reaction equation
Cl.Cl.[F:3][C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[Cl:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]([NH:28][C:29](=[O:31])[CH3:30])([CH3:27])[CH3:26])=[CH:21][CH:20]=1>>[ClH:17].[CH3:27][C:25]([NH:28][C:29](=[O:31])[CH3:30])([C:22]1[CH:23]=[CH:24][C:19]([CH2:18][N:14]2[CH2:13][CH2:12][N:11]([C:5]3[CH:6]=[CH:7][C:8]([F:10])=[CH:9][C:4]=3[F:3])[CH2:16][CH2:15]2)=[CH:20][CH:21]=1)[CH3:26]

Participants

3

Reactant 2

HCID 141267451-(2,4-Difluorophenyl)piperazine dihydrochlorideHCID 18423089N-(1-(4-chloromethylphenyl)-1-methylethyl)acetamide

Product 1

HCID 70037297N-(1-methyl-1-(4-((4-(2,4-difluorophenyl)piperazin-1-yl)methyl)phenyl)ethyl)acetamide hydrochloride

Procedure

By similar reaction and treatment to that in Example 1(5) using 1-(2,4-difluorophenyl)piperazine dihydrochloride instead of phenylpiperazine and N-(1-(4-chloromethylphenyl)-1-methylethyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide, the title compound was obtained as pale-brown crystals.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-8d05efb3e4554375b5678f983c67abc3
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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