1-(2,4-Difluorophenyl)piperazine → N-(1-(4-((4-(2,4-difluorophenyl)piperazin-1-yl)methyl)phenyl)propyl)acetamide

HRID 1282095Notes

Reaction equation

HRID 1282095 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.Cl[CH2:16][C:17]1[CH:22]=[CH:21][C:20]([CH:23]([NH:26][C:27](=[O:29])[CH3:28])[CH2:24][CH3:25])=[CH:19][CH:18]=1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:16][C:17]2[CH:18]=[CH:19][C:20]([CH:23]([NH:26][C:27](=[O:29])[CH3:28])[CH2:24][CH3:25])=[CH:21][CH:22]=2)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 27346371-(2,4-Difluorophenyl)piperazineHCID 18423118N-(1-(4-chloromethylphenyl)propyl)acetamide

Product 1

HCID 11523910N-(1-(4-((4-(2,4-difluorophenyl)piperazin-1-yl)methyl)phenyl)propyl)acetamide

Procedure

By similar reaction and treatment to that in Example 1(5) using 1-(2,4-difluorophenyl)piperazine instead of phenylpiperazine and N-(1-(4-chloromethylphenyl)propyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide, the title compound was obtained as pale-brown crystals, m.p.=137-138° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-06c9fc9a3d464701974cd64b35827218
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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