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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1282095Generated: October 26, 2026

1-(2,4-Difluorophenyl)piperazine → N-(1-(4-((4-(2,4-difluorophenyl)piperazin-1-yl)methyl)phenyl)propyl)acetamide

https://huagongshe.com/reaction/1282095

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2,4-Difluorophenyl)piperazineHCID 2734637—
ReactantN-(1-(4-chloromethylphenyl)propyl)acetamideHCID 18423118—
ProductN-(1-(4-((4-(2,4-difluorophenyl)piperazin-1-yl)methyl)phenyl)propyl)acetamideHCID 11523910—

Reaction Steps

By similar reaction and treatment to that in Example 1(5) using 1-(2,4-difluorophenyl)piperazine instead of phenylpiperazine and N-(1-(4-chloromethylphenyl)propyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide, the title compound was obtained as pale-brown crystals, m.p.=137-138° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06455528B1
Source datasetuspto-grants-2002_09
ORD IDord-06c9fc9a3d464701974cd64b35827218
Source noteuspto-grants-2002_09