1-(4-Fluorophenyl)piperazine dihydrochloride → N-(1-(4-(1-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)phenyl)-1-methylethyl)acetamide

HRID 1282107Notes

Reaction equation

HRID 1282107 reaction equation
Cl.Cl.[F:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1.Cl[CH:17]([C:19]1[CH:24]=[CH:23][C:22]([C:25]([NH:28][C:29](=[O:31])[CH3:30])([CH3:27])[CH3:26])=[CH:21][CH:20]=1)[CH3:18]>>[F:3][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH:17]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([NH:28][C:29](=[O:31])[CH3:30])([CH3:27])[CH3:26])=[CH:21][CH:20]=3)[CH3:18])[CH2:12][CH2:11]2)=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 162119161-(4-Fluorophenyl)piperazine dihydrochlorideHCID 18423053N-(1-(4-(1-chloroethyl)phenyl)-1-methylethyl)acetamide

Product 1

HCID 18422998N-(1-(4-(1-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)phenyl)-1-methylethyl)acetamide

Procedure

By similar reaction and treatment to that in Example 1(5) using 1-(4-fluorophenyl)piperazine dihydrochloride instead of phenylpiperazine and N-(1-(4-(1-chloroethyl)phenyl)-1-methylethyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide, the title compound was obtained as white crystals.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-892bc4b866ff4338805db7b82c3c889f
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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