1-(4-Fluorophenyl)piperazine dihydrochloride → N-(1-(4-(1-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)phenyl)-1-methylethyl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	1-(4-Fluorophenyl)piperazine dihydrochloride	HCID 16211916	—
Reactant	N-(1-(4-(1-chloroethyl)phenyl)-1-methylethyl)acetamide	HCID 18423053	—
Product	N-(1-(4-(1-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)phenyl)-1-methylethyl)acetamide	HCID 18422998	—

Reaction Steps

By similar reaction and treatment to that in Example 1(5) using 1-(4-fluorophenyl)piperazine dihydrochloride instead of phenylpiperazine and N-(1-(4-(1-chloroethyl)phenyl)-1-methylethyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide, the title compound was obtained as white crystals.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06455528B1
Source dataset	uspto-grants-2002_09
ORD ID	ord-892bc4b866ff4338805db7b82c3c889f
Source note	uspto-grants-2002_09