1-(2,4-Difluorophenyl)piperazine dihydrochloride → Methyl 1-(4-((4-(2,4-difluorophenyl)piperazin-1-yl)methyl)phenyl)cyclopropanecarboxylate

HRID 1282112Notes

Reaction equation

HRID 1282112 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]([O:14][CH3:15])=[O:13])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.Cl.Cl.[F:18][C:19]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[F:18][C:19]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=1[N:26]1[CH2:27][CH2:28][N:29]([CH2:2][C:3]2[CH:8]=[CH:7][C:6]([C:9]3([C:12]([O:14][CH3:15])=[O:13])[CH2:11][CH2:10]3)=[CH:5][CH:4]=2)[CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 141267451-(2,4-Difluorophenyl)piperazine dihydrochlorideHCID 18423090Methyl 1-(4-chloromethylphenyl)cyclopropanecarboxylate

Product 1

HCID 18422992Methyl 1-(4-((4-(2,4-difluorophenyl)piperazin-1-yl)methyl)phenyl)cyclopropanecarboxylate

Procedure

By similar reaction and treatment to that in Example 1(5) using methyl 1-(4-chloromethylphenyl)cyclopropanecarboxylate obtained in Example 75(2) instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(2,4-difluorophenyl)piperazine dihydrochloride instead of phenylpiperazine, the title compound was obtained as an orange oil.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-052efc0bbd9346839f8d581b82ad6606
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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