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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1282112Generated: November 4, 2026

1-(2,4-Difluorophenyl)piperazine dihydrochloride → Methyl 1-(4-((4-(2,4-difluorophenyl)piperazin-1-yl)methyl)phenyl)cyclopropanecarboxylate

https://huagongshe.com/reaction/1282112

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2,4-Difluorophenyl)piperazine dihydrochlorideHCID 14126745—
ReactantMethyl 1-(4-chloromethylphenyl)cyclopropanecarboxylateHCID 18423090—
ProductMethyl 1-(4-((4-(2,4-difluorophenyl)piperazin-1-yl)methyl)phenyl)cyclopropanecarboxylateHCID 18422992—

Reaction Steps

By similar reaction and treatment to that in Example 1(5) using methyl 1-(4-chloromethylphenyl)cyclopropanecarboxylate obtained in Example 75(2) instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(2,4-difluorophenyl)piperazine dihydrochloride instead of phenylpiperazine, the title compound was obtained as an orange oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06455528B1
Source datasetuspto-grants-2002_09
ORD IDord-052efc0bbd9346839f8d581b82ad6606
Source noteuspto-grants-2002_09