Piperazine → 1-(Thiazol-2-yl)piperazine

HRID 1282140Notes

Reaction equation

HRID 1282140 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Br[C:8]1[S:9][CH:10]=[CH:11][N:12]=1>O>[S:9]1[CH:10]=[CH:11][N:12]=[C:8]1[N:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 764302-Bromothiazole

Product 1

HCID 9118061-(Thiazol-2-yl)piperazine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
110 °C

Procedure

To piperazine (48 g) dissolved by heating at 110° C. was added dropwise 2-bromothiazole (5 ml) over 20 min. The mixture was stirred at 150° C. for 1 hr, poured into water (150 ml) and extracted with chloroform. The extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give the title compound (9.5 g) as a pale-yellow oil.

Workup

  1. extractionextracted with chloroform
  2. washThe extract was washed with saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated

Sources & evidence

ORD record
ord-dc67dc0667f94d6fa443061e34f327e0
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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