1-(Thiazol-2-yl)piperazine → N-(1-methyl-1-(4-((4-(thiazol-2-yl)piperazin-1-yl)methyl)phenyl)ethyl)acetamide

HRID 1282159Notes

Reaction equation

HRID 1282159 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH:12][C:13](=[O:15])[CH3:14])([CH3:11])[CH3:10])=[CH:5][CH:4]=1.[S:16]1[CH:20]=[CH:19][N:18]=[C:17]1[N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH3:10][C:9]([NH:12][C:13](=[O:15])[CH3:14])([C:6]1[CH:7]=[CH:8][C:3]([CH2:2][N:24]2[CH2:25][CH2:26][N:21]([C:17]3[S:16][CH:20]=[CH:19][N:18]=3)[CH2:22][CH2:23]2)=[CH:4][CH:5]=1)[CH3:11]

Participants

3

Reactant 2

HCID 9118061-(Thiazol-2-yl)piperazineHCID 18423089N-(1-(4-chloromethylphenyl)-1-methylethyl)acetamide

Product 1

HCID 11717426N-(1-methyl-1-(4-((4-(thiazol-2-yl)piperazin-1-yl)methyl)phenyl)ethyl)acetamide

Procedure

By similar reaction and treatment to that in Example 1(5) using N-(1-(4-chloromethylphenyl)-1-methylethyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(thiazol-2-yl)piperazine instead of phenylpiperazine, the title compound was obtained as pale-yellow crystals, m.p.=118-120° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-aa88b7b307804a659133df027fa3adcb
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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