4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine → N-(1-(4-((4-(4,6-dimethoxypyrimidin-2-yl)piperazin-1-yl)methyl)phenyl)-1-methylethyl)acetamide

HRID 1282164Notes

Reaction equation

HRID 1282164 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH:12][C:13](=[O:15])[CH3:14])([CH3:11])[CH3:10])=[CH:5][CH:4]=1.[CH3:16][O:17][C:18]1[CH:23]=[C:22]([O:24][CH3:25])[N:21]=[C:20]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[N:19]=1>>[CH3:16][O:17][C:18]1[CH:23]=[C:22]([O:24][CH3:25])[N:21]=[C:20]([N:26]2[CH2:27][CH2:28][N:29]([CH2:2][C:3]3[CH:8]=[CH:7][C:6]([C:9]([NH:12][C:13](=[O:15])[CH3:14])([CH3:11])[CH3:10])=[CH:5][CH:4]=3)[CH2:30][CH2:31]2)[N:19]=1

Participants

3

Reactant 2

HCID 50909284,6-Dimethoxy-2-(piperazin-1-yl)pyrimidineHCID 18423089N-(1-(4-chloromethylphenyl)-1-methylethyl)acetamide

Product 1

HCID 18423107N-(1-(4-((4-(4,6-dimethoxypyrimidin-2-yl)piperazin-1-yl)methyl)phenyl)-1-methylethyl)acetamide

Procedure

By similar reaction and treatment to that in Example 1(5) using N-(1-(4-chloromethylphenyl)-1-methylethyl)acetamide obtained in Example 95(4) instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(4,6-dimethoxypyrimidin-2-yl)piperazine obtained in Example 90(2) instead of phenylpiperazine, the title compound was obtained as white crystals, m.p.=199-202° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-ef0766707d184f199295415a7373029c
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

Loading…