4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine → N-(1-(4-((4-(4,6-dimethoxypyrimidin-2-yl)piperazin-1-yl)methyl)phenyl)-1-methylethyl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine	HCID 5090928	—
Reactant	N-(1-(4-chloromethylphenyl)-1-methylethyl)acetamide	HCID 18423089	—
Product	N-(1-(4-((4-(4,6-dimethoxypyrimidin-2-yl)piperazin-1-yl)methyl)phenyl)-1-methylethyl)acetamide	HCID 18423107	—

Reaction Steps

By similar reaction and treatment to that in Example 1(5) using N-(1-(4-chloromethylphenyl)-1-methylethyl)acetamide obtained in Example 95(4) instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(4,6-dimethoxypyrimidin-2-yl)piperazine obtained in Example 90(2) instead of phenylpiperazine, the title compound was obtained as white crystals, m.p.=199-202° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06455528B1
Source dataset	uspto-grants-2002_09
ORD ID	ord-ef0766707d184f199295415a7373029c
Source note	uspto-grants-2002_09