Water → 4-Methoxy-2-(piperazin-1-yl)pyrimidine

HRID 1282167Notes

Reaction equation

HRID 1282167 reaction equation
Cl[C:2]1[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][N:3]=1.[NH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.O>C(#N)C>[CH3:9][O:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[N:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 4837PiperazineHCID 5889352-Chloro-4-methoxypyrimidine

Product 1

HCID 114809874-Methoxy-2-(piperazin-1-yl)pyrimidineYield 90%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A suspension of 2-chloro-4-methoxypyrimidine (21.5 g) and piperazine (64.0 g) in acetonitrile (200 ml) was refluxed for 30 min. The reaction mixture was poured into water (500 ml) and extracted with chloroform (400 ml). The extract was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the title compound (26.0 g) as a pale-yellow oil.

Workup

  1. temperaturewas refluxed for 30 min
  2. extractionextracted with chloroform (400 ml)
  3. washThe extract was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated

Sources & evidence

ORD record
ord-5c2dcbca42a644a7b85acf3e1349d051
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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