HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl iodide → N-isopropyl-3-(m-trifluoromethylphenyl)-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | 3-[3-(Trifluoromethyl)phenyl]piperidine | HCID 3049031 | — |
| Catalyst | Silver(II) oxide | HCID 92152 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | N-isopropyl-3-(m-trifluoromethylphenyl)-piperidine | HCID 3049035 | — |
Reaction Steps
3.4 g of silver oxide were added to a solution of 9.2 g of 3-(m-trifluoromethylphenyl)-piperidine in 45 ml of acetone and after 61/2 hours of stirring 1.1 g of silver oxide and 4.9 ml of isopropyl iodide were added. The mixture was stirred for 24 hours and was filtered. The filtrate was evaporated to dryness to obtain 10.4 g of N-isopropyl-3-(m-trifluoromethylphenyl)-piperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04259337 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-0af35353fd894d2aa11a1d4b74bb8dad |
| Source note | uspto-grants-1981_03 |