Isopropyl iodide → N-isopropyl-3-(m-trifluoromethylphenyl)-piperidine

HRID 128217Notes

Reaction equation

HRID 128217 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([CH:9]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[CH:17](I)([CH3:19])[CH3:18]>CC(C)=O.[Ag]=O>[CH:17]([N:11]1[CH2:12][CH2:13][CH2:14][CH:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:15])[F:16])[CH:4]=2)[CH2:10]1)([CH3:19])[CH3:18]

Participants

5

Reactant 2

HCID 6362Isopropyl iodideHCID 30490313-[3-(Trifluoromethyl)phenyl]piperidine

Product 1

HCID 3049035N-isopropyl-3-(m-trifluoromethylphenyl)-piperidine

Reagents, catalysts & solvents 2

HCID 92152Silver(II) oxideCatalyst2×HCID 180AcetoneSolvent

Procedure

3.4 g of silver oxide were added to a solution of 9.2 g of 3-(m-trifluoromethylphenyl)-piperidine in 45 ml of acetone and after 61/2 hours of stirring 1.1 g of silver oxide and 4.9 ml of isopropyl iodide were added. The mixture was stirred for 24 hours and was filtered. The filtrate was evaporated to dryness to obtain 10.4 g of N-isopropyl-3-(m-trifluoromethylphenyl)-piperidine.

Workup

  1. additionwere added
  2. filtrationwas filtered
  3. customThe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-0af35353fd894d2aa11a1d4b74bb8dad
Source dataset
uspto-grants-1981_03
Patent number
US04259337

Reaction notes

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