1-(Thiazol-2-yl)piperazine → N-(1-(4-((4-(thiazol-2-yl)piperazin-1-yl)methyl)phenyl)ethyl)acetamide

HRID 1282171Notes

Reaction equation

HRID 1282171 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([NH:11][C:12](=[O:14])[CH3:13])[CH3:10])=[CH:5][CH:4]=1.[S:15]1[CH:19]=[CH:18][N:17]=[C:16]1[N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[S:15]1[CH:19]=[CH:18][N:17]=[C:16]1[N:20]1[CH2:21][CH2:22][N:23]([CH2:2][C:3]2[CH:8]=[CH:7][C:6]([CH:9]([NH:11][C:12](=[O:14])[CH3:13])[CH3:10])=[CH:5][CH:4]=2)[CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 9118061-(Thiazol-2-yl)piperazineHCID 18423033N-(1-(4-chloromethylphenyl)ethyl)acetamide

Product 1

HCID 11493939N-(1-(4-((4-(thiazol-2-yl)piperazin-1-yl)methyl)phenyl)ethyl)acetamide

Procedure

By similar reaction and treatment to that in Example 1(5) using N-(1-(4-chloromethylphenyl)ethyl)acetamide obtained in Example 48(3) instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(thiazol-2-yl)piperazine obtained in Example 81(1) instead of phenylpiperazine, the title compound was obtained as white crystals, m.p.=136-137° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-6f7a131e936a49dbb0d8d3a2c626014e
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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