1-(2-Pyridyl)piperazine → HCID 11709832, compound

HRID 1282173Notes

Reaction equation

HRID 1282173 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([NH:11][C:12](=[O:14])[CH3:13])[CH3:10])=[CH:5][CH:4]=1.[N:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[N:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:21]1[CH2:22][CH2:23][N:24]([CH2:2][C:3]2[CH:8]=[CH:7][C:6]([CH:9]([NH:11][C:12](=[O:14])[CH3:13])[CH3:10])=[CH:5][CH:4]=2)[CH2:25][CH2:26]1

Participants

3

Reactant 2

HCID 944591-(2-Pyridyl)piperazineHCID 18423033N-(1-(4-chloromethylphenyl)ethyl)acetamide

Product 1

HCID 11709832HCID 11709832, compound

Procedure

By similar reaction and treatment to that in Example 1(5) using N-(1-(4-chloromethylphenyl)ethyl)acetamide obtained in Example 48(3) instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(2-pyridyl)piperazine instead of phenylpiperazine, the title compound was obtained as pale-yellow crystals, m.p.=120-121° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-5977a734399f4b939bfd33060655a086
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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