4-Methoxy-2-(piperazin-1-yl)pyrimidine → HCID 18423049, compound

HRID 1282175Notes

Reaction equation

HRID 1282175 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH:12][C:13](=[O:15])[CH3:14])([CH3:11])[CH3:10])=[CH:5][CH:4]=1.[CH3:16][O:17][C:18]1[CH:23]=[CH:22][N:21]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[N:19]=1>>[CH3:16][O:17][C:18]1[CH:23]=[CH:22][N:21]=[C:20]([N:24]2[CH2:25][CH2:26][N:27]([CH2:2][C:3]3[CH:8]=[CH:7][C:6]([C:9]([NH:12][C:13](=[O:15])[CH3:14])([CH3:11])[CH3:10])=[CH:5][CH:4]=3)[CH2:28][CH2:29]2)[N:19]=1

Participants

3

Reactant 2

HCID 114809874-Methoxy-2-(piperazin-1-yl)pyrimidineHCID 18423089N-(1-(4-chloromethylphenyl)-1-methylethyl)acetamide

Product 1

HCID 18423049HCID 18423049, compound

Procedure

By similar reaction and treatment to that in Example 1(5) using N-(1-(4-chloromethylphenyl)-1-methylethyl)acetamide obtained in Example 95(4) instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(4-methoxypyrimidin-2-yl)piperazine obtained in Example 98(2) instead of phenylpiperazine, the title compound was obtained as white crystals, m.p.=160-162° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-ba238dcffd47408c8c8f5143d4406ca7
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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