4-Methoxy-2-(piperazin-1-yl)pyrimidine → HCID 18423183, compound

HRID 1282176Notes

Reaction equation

HRID 1282176 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([NH:11][C:12](=[O:14])[CH3:13])[CH3:10])=[CH:5][CH:4]=1.[CH3:15][O:16][C:17]1[CH:22]=[CH:21][N:20]=[C:19]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[N:18]=1>>[CH3:15][O:16][C:17]1[CH:22]=[CH:21][N:20]=[C:19]([N:23]2[CH2:24][CH2:25][N:26]([CH2:2][C:3]3[CH:8]=[CH:7][C:6]([CH:9]([NH:11][C:12](=[O:14])[CH3:13])[CH3:10])=[CH:5][CH:4]=3)[CH2:27][CH2:28]2)[N:18]=1

Participants

3

Reactant 2

HCID 114809874-Methoxy-2-(piperazin-1-yl)pyrimidineHCID 18423033N-(1-(4-chloromethylphenyl)ethyl)acetamide

Product 1

HCID 18423183HCID 18423183, compound

Procedure

By similar reaction and treatment to that in Example 1(5) using N-(1-(4-chloromethylphenyl)ethyl)acetamide obtained in Example 48(3) instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(4-methoxypyrimidin-2-yl)piperazine obtained in Example 98(2) instead of phenylpiperazine, the title compound was obtained as pale-yellow crystals, m.p.=113-115° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-3e35d75395624521a7cf5c2a26360229
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

Loading…