Ethanol → 1-Acetyl-4-(4,6-diethoxypyrimidin-2-yl)piperazine

HRID 1282177Notes

Reaction equation

HRID 1282177 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:15]=[C:14](F)[CH:13]=[C:12](F)[N:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[O-:18][CH2:19][CH3:20].[Na+].[CH2:22]([OH:24])[CH3:23]>>[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:15]=[C:14]([O:18][CH2:19][CH3:20])[CH:13]=[C:12]([O:24][CH2:22][CH3:23])[N:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 702EthanolHCID 2723922Sodium ethoxideHCID 184230501-Acetyl-4-(4,6-difluoropyrimidin-2-yl)piperazine

Product 1

HCID 184231661-Acetyl-4-(4,6-diethoxypyrimidin-2-yl)piperazine

Procedure

A solution of 1-acetyl-4-(4,6-difluoropyrimidin-2-yl)piperazine (1.5 g) and sodium ethoxide (1.3 g) in ethanol (15 ml) was refluxed under heating for 1 hr. The reaction mixture was poured into ice water and extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give the title compound (1.8 g) as a pale-brown solid.

Workup

  1. temperatureunder heating for 1 hr
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe solvent was evaporated

Sources & evidence

ORD record
ord-640140f4b36242b990d212a130664913
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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