Sodium Hydroxide → 3-[3-(Trifluoromethyl)phenyl]piperidine

HRID 128218Notes

Reaction equation

HRID 128218 reaction equation
Cl.[F:2][C:3]([F:17])([F:16])[C:4]1[CH:5]=[C:6]([CH:10]2[CH2:15][CH2:14][CH2:13][NH:12][CH2:11]2)[CH:7]=[CH:8][CH:9]=1.[OH-].[Na+]>O>[F:17][C:3]([F:2])([F:16])[C:4]1[CH:5]=[C:6]([CH:10]2[CH2:15][CH2:14][CH2:13][NH:12][CH2:11]2)[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 3049030Piperidine, 3-(3-(trifluoromethyl)phenyl)-, hydrochloride

Product 1

HCID 30490313-[3-(Trifluoromethyl)phenyl]piperidineYield 106.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5 g of 3-(m-trifluoromethylphenyl)-piperidine hydrochloride were dissolved in water and the solution was cooled on an ice bath and was made alkaline with sodium hydroxide. The mixture was extracted with ether and the ether were washed with water, dried over magnesium sulfate and evaporated to dryness under reduced pressure to obtain 4.6 g of 3-(m-trifluoromethylphenyl)-piperidine.

Workup

  1. temperaturethe solution was cooled on an ice bath
  2. extractionThe mixture was extracted with ether
  3. washthe ether were washed with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-5553b5e4735d42959ca515baba24d528
Source dataset
uspto-grants-1981_03
Patent number
US04259337

Reaction notes

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