HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-[3-(Trifluoromethyl)phenyl]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Piperidine, 3-(3-(trifluoromethyl)phenyl)-, hydrochloride | HCID 3049030 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-[3-(Trifluoromethyl)phenyl]piperidine | HCID 3049031 | 106.6% |
Reaction Steps
5 g of 3-(m-trifluoromethylphenyl)-piperidine hydrochloride were dissolved in water and the solution was cooled on an ice bath and was made alkaline with sodium hydroxide. The mixture was extracted with ether and the ether were washed with water, dried over magnesium sulfate and evaporated to dryness under reduced pressure to obtain 4.6 g of 3-(m-trifluoromethylphenyl)-piperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04259337 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-5553b5e4735d42959ca515baba24d528 |
| Source note | uspto-grants-1981_03 |