1-(6-fluoropyridin-2-yl)piperazine → (S)-N-(1-(4-((4-(6-fluoropyridin-2-yl)piperazin-1-yl)methyl)phenyl)ethyl)acetamide

HRID 1282196Notes

Reaction equation

HRID 1282196 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]([NH:11][C:12](=[O:14])[CH3:13])[CH3:10])=[CH:5][CH:4]=1.[F:15][C:16]1[N:21]=[C:20]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH:19]=[CH:18][CH:17]=1>>[F:15][C:16]1[N:21]=[C:20]([N:22]2[CH2:27][CH2:26][N:25]([CH2:2][C:3]3[CH:8]=[CH:7][C:6]([C@@H:9]([NH:11][C:12](=[O:14])[CH3:13])[CH3:10])=[CH:5][CH:4]=3)[CH2:24][CH2:23]2)[CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 37288181-(6-fluoropyridin-2-yl)piperazineHCID 53659736(S)-N-(1-(4-(Chloromethyl)phenyl)ethyl)acetamide

Product 1

HCID 15549973(S)-N-(1-(4-((4-(6-fluoropyridin-2-yl)piperazin-1-yl)methyl)phenyl)ethyl)acetamide

Procedure

By similar reaction and treatment to that in Example 1(5) using (S)-N-(1-(4-chloromethylphenyl)ethyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(6-fluoropyridin-2-yl)piperazine obtained in Example 85(2) instead of phenylpiperazine, the title compound was obtained as a pale-yellow oil.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-0880440ed607436aad4505b29f708aa0
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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